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The diagnosis and treatment of many diseases depend heavily on pathology labs. These labs carry out a variety of tests on samples like blood, tissue, and urine to help medical professionals make precise diagnoses and develop efficient treatment procedures.

Pathology labs employ the CPT coding system to ensure they get paid for their services. Depending on the kind of test or service rendered, a wide range of CPT codes are utilized in pathology labs. These codes can be for basic blood testing or detailed genetic analysis.

Importance of Pathology Lab Procedures

Procedures used in pathology labs are essential in the healthcare sector because they help with the early detection, diagnosis, and treatment of various disorders.

The fact that pathology lab procedures give physicians vital knowledge about a patient’s health status is one of the most significant reasons they are crucial. These tests’ findings enable clinicians to provide precise diagnoses, which may result in prompt treatment and better patient outcomes. For instance, a biopsy performed by a pathology lab can detect cancerous cells, which can encourage doctors to start cancer therapy right away.

Also: CPT Codes for Neurosurgery

Additionally, pathology lab procedures are crucial since they assist medical professionals in tracking the development of illnesses and treatment efficacy. Doctors can monitor changes in a patient’s health and modify treatment plans as necessary by routinely examining blood samples or other bodily fluids.

Please continue reading to obtain detailed information on the CPT Codes significant for pathology lab procedures:

  • 88305 – Level IV – Surgical pathology, gross and microscopic examination:

This code applies to a surgical pathology examination that includes microscopic and gross (or study with the human eye and a magnifying glass) examination of tissue specimens. Level IV denotes a demanding test requiring a higher level of knowledge.

  • 88307 – Level V – Surgical pathology, gross and microscopic examination:

A surgical pathology examination that is even more intricate than the one covered by 88305 is covered by this code. It likewise involves the microscopic and gross inspection of tissue samples, but it is more sophisticated and requires more knowledge.

  • 88309 – Level VI – Surgical pathology, gross and microscopic examination:

This code is applied to the most complicated and highly specialized surgical pathology tests. The study of tissue samples under the microscope and in gross aspect is also included.

  • 88173 – Cytopathology, evaluation of fine needle aspirate with interpretation and report:

This code is used to assess a fine needle aspirate, a process that involves taking a sample of cells from a suspicious location of the body with the help of a little needle. It is inspected under a microscope to assess whether the sample is cancerous. This code includes instructions for analyzing the sample, interpreting the findings, and writing a report summarizing the results.

  • 88342 – Immunohistochemistry or immunocytochemistry, per specimen; each additional single antibody stain procedure:

Using antibodies to identify particular proteins in tissue or cell samples, immunohistochemistry, and immunocytochemistry processes use this code. One antibody stain technique per specimen, together with any additional single antibody stain procedures that might be required, are covered by this code.

  • 88141 – Cytopathology, slide preparation, and examination, cervical or vaginal (Pap smear):

This CPT code prepares and examines a cervical or vaginal Pap smear. A sample of cells from the cervix or vagina is taken, prepared on a slide, and examined under a microscope for abnormal cells. Pap smears are frequently used to diagnose abnormalities such as cervical cancer early.

  • (88367 – 88369) – Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), DNA or RNA, manual or computer-assisted:

In situ, hybridization, a method that makes it possible to see particular nucleic acid sequences within cells or tissues, is used to examine DNA or RNA using this CPT code. The analysis can be carried out manually or with computer-assisted technology. The code is applied to each multiplex probe analyzed for each specimen.

  • 88381 – Microdissection, manual:

The manual microdissection of tissue samples is done using this CPT code. The microdissection technique is used to isolate particular cells or sections of tissue to perform further analysis. The procedure manually dissects and separates the target cells or tissue using a scalpel or other tool.

  • 88311 – Decalcification procedure:

Decalcification is a particular kind of tissue preparation technique described by this code. Calcium deposits in some tissue types, such as bone, may affect a pathology investigation. This code is added to the surgical pathology examination code to show that decalcification was done.

  • 88342 – Tumor immunohistochemistry, each antibody:

Immunohistochemistry (IHC), a form of analysis used to identify specific proteins or other compounds in a tissue sample, is denoted by this code. This code describes the breakdown of each antibody utilized and specifically applies to examining tumor samples.

Also: CPT Codes for Hepatology

Other CPT Codes for Speech Pathologists

  1. 92507 – Speech/hearing therapy: To treat a range of communication disabilities, including but not limited to articulation, language, voice, fluency, and cognitive-communication issues, this code is used for individual speech or language therapy services delivered by a professional speech-language pathologist (SLP).
  2. 92517 – Vemp test i&r cervical: To measure the electrical reactions of the muscles involved in balance and posture, electrodes are placed on the scalp and neck during the test.
  3. 92521 – Evaluation of speech fluency: A professional SLP will use this code to assess fluency issues like cluttering and stuttering. The evaluation thoroughly assesses the patient’s language skills, speech patterns, and rate and rhythm.
  4. 96105 – Assessment of aphasia: This code is used to evaluate aphasia, a communication condition that affects a person’s capacity for language use in speech, writing, and comprehension. The assessment may include language testing, cognitive-linguistic testing, and evaluating communication abilities.


Pathology labs must use CPT codes precisely to achieve proper billing and reimbursement and maintain compliance with healthcare standards. CPT codes must be used to ensure that patients receive the best care possible and that pathology labs receive an adequate refund for their services.

Furthermore, by knowing CPT codes, laboratories can spot patterns in testing and utilization and decide appropriately on their services and prices.

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